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  • 04 Feb 2024 3:09 PM | Ling Qin (Administrator)

    ABOUT ANGITIA:

    Founded in 2018, Angitia is a clinical-stage biotechnology company focused on the discovery and development of breakthrough therapeutics that address the key unmet medical needs in serious musculoskeletal diseases. With the team’s experience and scientific expertise in novel drug development, Angitia is dedicated to bringing innovative therapies to help patients worldwide.

    Please visit us at www.angitiabio.com or scan below QR code for Angitia Wechat official account to learn more.


    JOB SUMMARY:

    We are seeking an exceptional senior scientist (titled Principal Scientist to Sr. Research Director commiserate on experience and expertise) to join the pre -clinical pharmacology team in Translational Science. The primary focus of the department is to translate newly discovered biological targets and pioneering therapeutics using preclinical animal models to inform human disease for drug candidate selection and progression to clinical trials. The ideal candidate will oversee and manage the preclinical pharmacology laboratory, including experimental protocol design and execution. The individual in this position will report to the Senior Vice President of Translational Science, and be responsible for managing a laboratory of 5-7 junior scientists while designing, conducting, and analyzing in vitro and in vivo experiments employing various experimental approaches. Additionally, as the head of the laboratory, the individual will be responsible for instituting appropriate protocols, laboratory safety, and SOPs, while maintaining meticulous data documentation (including oversight of team member notebooks, and data organization and storage), instrumentation and supplies. Our research areas comprise of, but are not limited to, new drug discovery and development for severe musculoskeletal disorders such as osteoporosis, osteogenesis imperfecta, and other disorders related to bone, cartilage, and muscle. An ideal candidate is a seasoned scientist who has spent a considerable amount of training in the musculoskeletal field, has extensive experience and expertise in utilizing various animal models of human musculoskeletal diseases, as well as in molecular and cell biology techniques.

    JOB RESPONSIBILITIES:

    1. Supervises work of lab team, including planning, assigning and scheduling work, reviewing work and ensuring quality data standards, training staff and overseeing their productivity. May offer recommendations for hiring, termination and pay adjustments.

    2. Maintains laboratory productivity by monitoring the workload of functional areas.

    3. Designs, plans, oversees, and independently performs in-vivo experiments using small and larger animal models to dissect complex molecular phenotypes associated with human disease findings in musculoskeletal disease field.

    4. Designs and tests the biology of novel molecules in specific in-vitro and/or ex-vivo cell- based

    systems.

    5. Implements new programs, tests, methods, and instrumentation.

    6. Identifies informational needs to manage laboratory information systems.

    7. Establishes quality standards to maintain laboratory safety protocols, SOPs and laboratory equipment use and performance.

    8. Oversees laboratory expenses and costs, while keeping supplies stocked by determining inventory level.

    9. Meets during weekly lab meetings with other technical personnel to ensure all lab procedures and equipment are working well and institute improvements when needed.

    10. Prepares and presents study reports and data analyses.

    11. Drafts regulatory documents in support of drug development.

    12. Prepares manuscripts for scientific publications.

    13. Collaborates with cross functional teams within the company as well as external CROs and collaborators that support the drug development pipeline.

    QUALIFICATIONS:

    1. PhD or equivalent degree in the field of biomedical science (biochemistry, physiology, and pharmacology, etc.) and a minimum of 4 years of research experience in musculoskeletal disease area with good track record of scientific presentations and publications.

    2. Demonstrated experience in in vivo studies, proficient with microscopy / histology tissue process and analysis.

    3. Hands-on experience in molecular and cellular biology techniques including qPCR, Western Blots, cell culture, ELISA, and more.

    4. Demonstrated ability to troubleshoot and solve complex problems.

    5. Demonstrated management skills that include training and oversight of junior researchers.

    6. Ability to manage heavy workload, demands on time and resources and prioritize effectively. 7. Effective oral, written, communication skills in English and Chinese are required.

    8. Able to excel in a fast-track environment while requiring multi-tasking across multiple projects.

    ANGITIA CONTACT:

    Email:

    jessica.zheng@angitiabio.com(Human Resources)

    ann.zovein@angitiabio.com(Hiring Manager)


  • 23 Apr 2023 2:04 PM | Bingyun Li

    Job Posting for Postdoctoral (PDF) Positions at Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital/Shanghai Institute of Traumatology and Orthopedics.

    Collaborating Supervisor: Prof. William Lu, PDF co-supervisor at the Shanghai Jiao Tong University School of Medicine affiliated Ruijin Hospital. He is a Professor at the Department of Orthopaedics and Traumatology at the University of Hong Kong (HKU), Affiliate Research PI at the Human Tissue and Organ Degeneration Center of the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences.

    Contact Information:

    Phone: 021-80527433

    E-mail: Dr. Bo Chen, cb88cb@hotmail.com ; wwlu@hku.hk,

    Positions offered and Requirements:

    • ·         Priority is given to the fields of orthopedic-related biomaterials, 3D printing, mechanical design, and innovative Al related research and development.
    • ·         The annual salary is 280,000-340,000 RMB, including a basic salary of 180,000-240,000 RMB, with additional performance bonuses.
    • ·         National and Shanghai social insurance and housing fund policies will be followed. Postdoctoral researchers are encouraged and supported to apply for various postdoctoral funding projects and talent programs, participate in international academic exchanges (overseas exchange projects), and assist the growth and development of young talents.
    • ·         Selected candidates for the National "Postdoctoral Innovative Talents Support Program" and the Shanghai "Super Postdoctoral Support Program” can enjoy various talent training projects, incentives, and scientific research funding.
    • ·         Excellent postdoctoral researchers who are discharged from the PDF can apply for full-time positions through the hospital's annual open recruitment process, and outstanding performers will be recommended to apply for positions as associate research fellows (Associate Professor).
    • ·         Postdoctoral researchers can enjoy employee subsidies,including meal, medical examinations, dining discounts, and priority policies for outpatient treatment. Assistance will be provided in processing Shanghai household registration and applying for Shanghai talent apartments.


    上海交通大学医学院附属瑞金医院/上海市伤骨科研究所招收博士后

    合作导师:吕维加教授

    上海交通大学医学院附属瑞金医院广慈教授,香港大学矫形及创伤外科学系教授,伍振民基金教授(骨科生物工程)研究部主任,中国科学院深圳先进技术研究院医药所人体组织与器官退行性中心研究员,首席科学家,香港工程师学会生物医学分部前主席。(JBMR)编委。

    联系电话:021-80527433

    联系邮箱:Dr. Bo Chen cb88cb@hotmail.com, wwlu@hku.hk

    招收方向及要求:

    1.重点考虑骨科相关生物材料、3D打印、机械设计、创成式AI研发等专业方向。

    2.年薪28-34万,其中基本薪酬18-24万,科研绩效奖励另计。

    3.根据国家和上海市政策缴纳社会保险和住房公积金。

    4.鼓励并支持博士后申请各类博士后基金项目和人才计划,参加国际学术交流(境外交流

    项目),助力青年人才成长和发展。

    5.入选国家”博士后创新人才支持计划”、上海市”超级博士后”,可享受各类人才培养项目在岗津贴和科研经费。

    6.优秀博士后出站,可通过医院当年度公幵招聘方式,优先全职入编上海交通大学医学院附属瑞金医院/上海市伤骨科研究所. 业绩突岀者将推荐 申请副研究员岗位。

    7.          享有员工伙食补贴、员工体检、就餐优惠、门诊就医优先政策等。

    8.          协助办理上海户籍、申请上海市人才公寓。

  • 23 Nov 2022 10:08 PM | Bingyun Li

    The Song Laboratory at the UMass Chan Medical School (www.umassmed.edu/songlab/), located in Worcester, Massachusetts, is seeking to fill a Postdoctoral Fellow opening on the development of orthopedic biomaterials (e.g. shape memory polymers, anti-infective coatings, synthetic viscoelastic hydrogels). This position requires a recent PhD degree in synthetic organic/polymer chemistry, materials sciences, chemical biology or a closely related field. The candidate is expected to work both independently and collaboratively in a multidisciplinary team environment. Applicants are required to have hands-on experience in organic/polymer synthesis and characterization of mechanical/biological properties of synthetic materials. Prior cell culture and animal work experience is preferred but not required. Research in the Song lab has been funded by the NIH and various non-for-profit foundations.

    Interested candidates should send a cover letter explaining research interests and career goals, along with a copy of CV and the contact information for three references to Dr. Jie Song by email: Jie.Song@umassmed.edu.

  • 05 Jul 2022 12:06 PM | Zhenqiang Yao

    Job Description

    Two postdoctoral positions are available immediately in the Department of Pathology & Laboratory Medicine at the University of Rochester Medical Center to work on the basic and translational research related to musculoskeletal disease and breast cancer, funded by multiple NIH R01 and DoD research projects. The musculoskeletal disease project will focus on the interactions among T lymphocytes, macrophage and osteoblasts during aging to cause osteoporosis and immunosenescence through TGFb1-mediated TRAF3 lysosomal degradation and evaluate the effect of our recently patented bone-targeted lysosomal inhibitor on the prevention and treatment of osteoporosis and immunosenescence. The research will involve in sophisticated genetical mouse models, cell fate mapping using flow cytometry coupled with single-cell transcriptomics, three-dimensional imaging and histomorphometry analysis. The breast cancer project will evaluate the effect of a novel engineered macrophage and microbiota-derived LPS on the treatment of metastatic breast cancer in humanized immunocompromised mice coupled with patient-derived xenograft model.

    Qualifications

    The applicants must have a PhD, MD or MD/PhD degree, be highly motivated with a strong motivation to work independently with good writing and oral communication skills. Prior experience in small animal handling/surgery, flow cytometry, cell culture, immunostaining /confocal microscopy imaging is preferred. Experience in analysis of single cell and bulk RNA-seq, gene cloning, bone histomorphometry, mouse tail vein injection and bone marrow transplantation would be a plus.

    To apply for these positions, please email a cover letter and C.V. to:
    Zhenqiang Yao, Ph.D.
    Associate Professor
    Department of Pathology & Laboratory Medicine
    University of Rochester Medical Center
    601 Elmwood Ave., Room 5-7545B
    Rochester, NY 14642
    zhenqiang_yao@urmc.rochester.edu

     



  • 21 Jun 2022 1:42 PM | Bingyun Li

    The Mechanics of Biological Materials/Structures Laboratory at the University of Texas at San Antonio (UTSA) is seeking to fill a Postdoctoral Research Associate position working on a NIH supported research project. In this project, we intend to elucidate the effect of proteoglycans on the age-related deterioration of bone quality and to develop therapeutic strategies for preventing or deterring such adverse effect. This position requires a PhD degree in Mechanical Engineering, Biomedical Engineering, Materials Science/Engineering, or a closely related field and willingness to work in a multidisciplinary (engineering, biology, and physics) environment. The incumbent is expected to take a leading role in implementation of the research project and required to help mentor graduate and undergraduate students, publish high impact journal papers, and write grants. Applicants are required to have hands-on experience in characterization of mechanical/compositional properties of bone or other biological materials. In addition, experiences in AFM and finite element simulations are preferred.

    Interested candidates should send the application as one PDF file containing a letter (explaining research interests, career goals, and qualifications), a CV, and the contact information of at least three references to Dr. Xiaodu Wang using the following contact information:

    Xiaodu Wang, Ph.D., Professor, Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249; Email: xiaodu.wang@utsa.edu; Tel: 1-210-458-5565.

  • 16 Jan 2022 6:41 PM | Bingyun Li

    Contact Info:

    Professor Yunzhi Peter Yang, ypyang@stanford.edu

    Description:

    One postdoctoral position in bone biology and/or stem cell biology is available immediately in the lab of Professor Yunzhi Peter Yang, Departments of Orthopedic Surgery at Stanford University at https://med.stanford.edu/yanglab.html. The candidates with strong biology and surgery experimental experience and interest in the areas of tissue regeneration is sought to participate in the NIH and DOD funded projects. The Lab particularly emphasizes development of multidisciplinary and novel approaches to address relevant biomedical questions in musculoskeletal tissue applications. Highly motivated candidates with experimental background, strong academic and publication record, and the ability to work independently and collaboratively with a strong commitment are invited to apply. Interested candidates should send a cover letter, their CV, and the names and contact information of three references electronically to the email address given below, ypyang@stanford.edu. The positions are open immediately.

    Qualifications:

    The postdoctoral fellow will participate in the projects involving stem cells and requires a strong background in stem cell biology, bone biology, genetic editing and surgical skills in orthopedic trauma and tendon injury in vivo models. The applicants who have abundant experience with cell culture, RNA extraction, qRT-PCR, bioinformatic analysis, tissue analysis techniques, such as paraffin embedding, tissue sectioning, immunohistological staining, histomorphometry, micro-CT, and mechanical tests, and orthopaedic surgery for rodents are highly encouraged for application.

  • 18 Nov 2021 5:05 PM | Bingyun Li

    Postdoctoral Scholar in Skeletal Stem Cell Biology 

    A postdoctoral position is available in the Department of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, to study stem cells in skeletal development and diseases.  

    We take advantage of multi-disciplinary approaches including advanced single cell transcriptomics, sophisticated genetical mouse models and surgery-induced disease models, and cutting-edge three dimensional imaging, to identify mesenchymal subpopulations in bone and joint tissues and to understand their functions and regulatory mechanisms under physiological and pathological conditions. UPenn is a highly collaborative environment. We are currently collaborating with multiple other research laboratories specializing in nanomaterial, biomechanics, tissue engineering, adipose biology, and bioinformatics with a goal of translating our projects into future clinical applications. Several exciting projects are available for the candidate to choose from, covering the areas of bone remodeling, marrow adipocytes, joint biology, and tissue regeneration. Please refer to our recent publications (Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. Elife e54695; MALPs promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest. JCI e140214; Targeting cartilage EGFR pathway for osteoarthritis treatment. Sci Transl Med. eabb39461) and lab website (https://www.med.upenn.edu/orl/qinlab/) for more information. 

    The candidate must be self-motivated, have strong background in standard molecular and biological techniques, cell culture and/or animal model, and have genuine interests in developing computational skills for single cell data and imaging analyses. Previous experience in skeletal stem cell biology is preferred but not required. The position requires the ability to lead projects and work cooperatively with others, carry out and troubleshoot experiments, and assist in grant and manuscript writing. The salary and benefit will follow the NIH standard. 

    Please email a letter of application, curriculum vitae, and names of three references to: Ling Qin, Ph.D., Associate Professor, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, qinling@pennmedicine.upenn.edu 


  • 15 Jun 2021 8:59 AM | Anonymous

    A postdoctoral position is available in the laboratory of Harry Kim, MD (Professor of Orthopedic Surgery at UT Southwestern and Direct of Hip Center at Scottish Rite for Children). Dr. Kim leads a very productive research team composed of material scientist, bone biologist, bioengineer, and histology and animal technologists. His NIH funded work seeks to develop new biologic and immunologic therapies for hip and joint disorders and osteoarthritis using in vivo and in vitro models. Projects related to bone tissue engineering and osteoimmunology are available for the candidate.

    Essential responsibilities:

    1. Design, synthesize, and characterize biomaterials and scaffolds.

    2. Perform cell culture experiments and biological assays.

    3. Assist with animal studies and tissue analysis.

    4. Analyze and prepare presentations and manuscripts.

    Prerequisite Qualifications:

    Applicant must have a PhD or equivalent in Regenerative Medicine, Biological Engineering, or Materials and Polymers. Candidate with experience in biomaterials fabrication and characterization, cell culture and biological assays will be given priority for interview.

    Please contact:

    Chi Ma Ph.D

    Scientist, Department of Research

    Texas Scottish Rite Hospital for Children

    Assistant Professor, Department of Orthopaedic Surgery

    UT Southwestern Medical Center

    chi.ma@tsrh.org


  • 11 May 2021 8:28 AM | Anonymous

    Applications are invited for a post-doctoral fellowship position within the Biomechanics Section of the Bone and Joint Center Research Laboratories at Henry Ford Health System (Detroit, MI). The successful applicant  will initially be involved with DOD-funded clinical projects focused on assessment of bone quality using new methods based on digital tomosynthesis imaging, and identifying strategies for successful implementation. The candidate will also be expected to advance existing projects as well as develop and lead new projects. Support for career development will be available for motivated individuals.

    Applicants should have a Ph.D. in Mechanical Engineering, Biomedical Engineering or a related field. Preference will be given to applicants with demonstrated research potential, a record of peer-reviewed publications, a strong desire for multidisciplinary collaborations, and expertise that is complementary to the Bone & Joint Center’s existing capabilities. A strong work ethic and excellent oral/written communication skills are also essential. Experience in musculoskeletal image analysis is desired but not required. The initial appointment will be for 12 months, with additional 12-month extensions available based on performance.

    The Bone & Joint Center is a multidisciplinary research team with expertise in a range of orthopaedic disciplines including cell/molecular biology, genomics, biomechanics, and imaging. Scientists in the Bone & Joint Center have a strong history of collaboration with the Departments of Orthopedic Surgery, Rheumatology, Radiology, Public Health Science, and Endocrinology at Henry Ford Health System. The Bone & Joint Center is located within new laboratory space in Wayne State University’s state-of-the-art Integrative Biosciences Center. Additional information can be found at https://www.hfhs-bjc.org/.

    Applicants should submit their CV, a statement of research interests and career goals, and contact information for three references, to Yener N. Yeni, PhD at yeni@bjc.hfh.edu. Anticipated start is September 2021, but it is negotiable. Review of applicants will begin immediately and will continue until the position is filled.

    Henry Ford Hospital is an AA/EO Employer.

    Click here for the PDF version of this announcement.

  • 22 Apr 2021 12:11 PM | Anonymous

    A postdoctoral position is available immediately in the laboratory of Dr. Boyce, Department of Pathology and Laboratory Medicine and the Center for Musculoskeletal Research at the University of Rochester Medical Center, Rochester, New York, following the successful renewal of an NIH RO-1 grant that has been funded continuously since 1995. Dr. Boyce is a surgical pathologist specializing in the diagnosis of bone and soft tissue diseases and a basic scientist with an interest in the regulation of bone turnover in normal and pathologic conditions. Work in our lab has focused on the role of NF-kB signaling in the formation and activity of osteoclasts and osteoblasts, following our discovery >25 years ago that NF-kB positively regulates osteoclast formation. Current work focuses on the role of TRAF3/NF-kB in osteoclast precursors as a negative regulator of RANKL-induced osteoclast formation and also as a negative regulator of TGFb-induced inhibition of mesenchymal progenitor cell (MPC) differentiation into osteoblasts. Through this work, we have identified a novel subset of B cells that express RANKL and CXCR4 and found that their numbers are increased in the bone marrow (BM) of mice with TRAF3 conditionally deleted in osteoclast precursors and are the most abundant RANKL-expressing cells in BM of aging mice.  We hypothesize that these cells are attracted to the BM during aging by MPCs that have increased expression of CCL12, a ligand for CXCR4, as a result of NF-kB-induced low-level chronic inflammation of aging, and cause age-related increased bone resorption. We plan to fully characterize these cells phenotypically using flow cytometry and single cell and bulk RNA-seq, map their locations in bone using a Fluidigm Hyperion CyTOF platform, and determine if: 1) they accumulate in BM of aging humans; 2) CXCR4 in B cells mediates their accumulation in the BM of aging mice by conditionally deleting CXCR4 in B cells; 3) TRAF3 expressed by MSCs regulates the accumulation of these B cells in BM by modulating SDF1 expression; 4) plerixafor (a CXCR4 inhibitor) prevents age-related osteoporosis by depleting RCBs from BM; 5) and if targeting plerixafor to bone by linking it to a bisphosphonate increases its efficacy and reduces its adverse effects.

    EDUCATION AND EXPERIENCE REQUIRED

    The applicants must have a PhD, MD or MD/PhD degree, be highly motivated with a strong motivation to work independently with good writing and oral communication skills. Prior experience in musculoskeletal skeletal research, histomorphometry and flow cytometry is preferred, and in single cell and bulk RNA-seq would be a plus.


    APPLICATION REQUIREMENTS

    To apply for this position, please email a cover letter and C.V. to:

    brendan_boyce@urmc.rochester.edu


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