A postdoctoral position is available immediately in the laboratory of Dr. Boyce, Department of Pathology and Laboratory Medicine and the Center for Musculoskeletal Research at the University of Rochester Medical Center, Rochester, New York, following the successful renewal of an NIH RO-1 grant that has been funded continuously since 1995. Dr. Boyce is a surgical pathologist specializing in the diagnosis of bone and soft tissue diseases and a basic scientist with an interest in the regulation of bone turnover in normal and pathologic conditions. Work in our lab has focused on the role of NF-kB signaling in the formation and activity of osteoclasts and osteoblasts, following our discovery >25 years ago that NF-kB positively regulates osteoclast formation. Current work focuses on the role of TRAF3/NF-kB in osteoclast precursors as a negative regulator of RANKL-induced osteoclast formation and also as a negative regulator of TGFb-induced inhibition of mesenchymal progenitor cell (MPC) differentiation into osteoblasts. Through this work, we have identified a novel subset of B cells that express RANKL and CXCR4 and found that their numbers are increased in the bone marrow (BM) of mice with TRAF3 conditionally deleted in osteoclast precursors and are the most abundant RANKL-expressing cells in BM of aging mice.  We hypothesize that these cells are attracted to the BM during aging by MPCs that have increased expression of CCL12, a ligand for CXCR4, as a result of NF-kB-induced low-level chronic inflammation of aging, and cause age-related increased bone resorption. We plan to fully characterize these cells phenotypically using flow cytometry and single cell and bulk RNA-seq, map their locations in bone using a Fluidigm Hyperion CyTOF platform, and determine if: 1) they accumulate in BM of aging humans; 2) CXCR4 in B cells mediates their accumulation in the BM of aging mice by conditionally deleting CXCR4 in B cells; 3) TRAF3 expressed by MSCs regulates the accumulation of these B cells in BM by modulating SDF1 expression; 4) plerixafor (a CXCR4 inhibitor) prevents age-related osteoporosis by depleting RCBs from BM; 5) and if targeting plerixafor to bone by linking it to a bisphosphonate increases its efficacy and reduces its adverse effects.

EDUCATION AND EXPERIENCE REQUIRED

The applicants must have a PhD, MD or MD/PhD degree, be highly motivated with a strong motivation to work independently with good writing and oral communication skills. Prior experience in musculoskeletal skeletal research, histomorphometry and flow cytometry is preferred, and in single cell and bulk RNA-seq would be a plus.

APPLICATION REQUIREMENTS

To apply for this position, please email a cover letter and C.V. to:

brendan_boyce@urmc.rochester.edu

The Department of Biomedical Engineering at Southern University of Science and Technology has 2 fully-funded postdoctoral fellow positions, available immediately. The successful candidate will be working in Dr. Chao Liu’s research group. The laboratory is well-equipped to study the mechanobiology of stem cell populations during bone repair, and tissue engineering of bone tissue for regenerative medicine applications.

 

Qualifications

Recent PhD with training documented by publications in international peer-reviewed journals. Successful applicants should have background in biomedical engineering, mechanical engineering, tissue engineering or a related discipline. Knowledge of programming, finite element analysis, in vitro mechanobiology models, and small animal models preferred.

Please send CV and contact information of three references to: Dr. Chao Liu, Email: liuc33@sustech.edu.cn

 

About the university

Southern University of Science and Technology (SUSTech) is a public university, founded in the lush hills of Nanshan District, Shenzhen, China. It is working towards becoming a world-class university excelling in interdisciplinary research, nurturing innovative talents and delivering new knowledge to the world.

A postdoctoral position is available immediately in Dr. Ling Qin’s laboratory in the Department of Orthopaedic Surgery at the University of Pennsylvania. Our group uses cutting edge histology, 3D imaging, and single cell sequencing techniques as well as mouse models to study bone and cartilage metabolism and skeletal development. Several exciting projects are available for the candidate to choose from, covering the areas of bone turnover, stem cells, marrow adipocytes, joint biology, and tissue regeneration. Please refer to our recent publications (Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. Elife e54695; MALPs promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest. Online; Targeting cartilage EGFR pathway for osteoarthritis treatment. Sci Transl Med. In press) and lab website (https://www.med.upenn.edu/orl) for more information about research interests and collaborative research environment.  

The candidate must be self-motivated, have strong background in standard molecular and biological techniques, cell culture and/or animal model, and have genuine interests in developing computational skills for single cell data and imaging analyses. Previous experience in bone biology is preferred but not required. The position requires the ability to lead projects and work cooperatively with others, carry out and troubleshoot experiments, and assist in grant and manuscript writing. 

Please email a letter of application, curriculum vitae, and names of three references to: Ling Qin, Ph.D. 

Associate Professor 

Department of Orthopaedic Surgery 

Co-Director, PCMD Histology Core 

University of Pennsylvania 

311A Stemmler Hall 

36th Street and Hamilton Walk 

Philadelphia, PA 19104 

qinling@pennmedicine.upenn.edu 

Applications are invited for appointment as Research Assistant Professor in the Department of Orthopaedics and Traumatology (Ref.: 502109), to commence as soon as possible on a two- to three-year fixed-term basis, with the possibility of renewal.

Applicants should possess a Ph.D. degree in Bio-Engineering or related disciplines, with an excellent publication track record.  They should be organised, self-motivated, and able to work independently as well as in a team; have demonstrated experience in high impact basic research and translational research; and have excellent written and oral communication skills in English and Chinese.  Proficiency in machine learning, computer vision modelling and FEM would be an advantage. 

The appointee will be leading small- and large-scale research studies from start to finish.  He/She will closely work with clinicians, academic research and industrial partners; participate in cross-disciplinary and cross-institute collaborations; conduct high-impact research; write scientific publications and grant proposals; contribute to postgraduate and undergraduate teaching; and provide supervision and training for postgraduate students. 

A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.  At current rates, salaries tax does not exceed 15% of gross income.  The appointment will attract a contract-end gratuity and University contribution to a retirement benefits scheme, totaling up to 15% of basic salary. 

The University only accepts online application for the above post.  Application should apply online and upload an up-to-date C.V.  Review of applications will start on September 22, 2020 and continue until November 30, 2020, or until the post is filled, whichever is earlier.

Click here to apply for this job

THE HONG KONG POLYTECHNIC UNIVERSITY

Department of Biomedical Engineering

Dr. Xin Zhao’s Lab

Vacancy Announcement 

Post Specification

Two postdoctoral fellow positions are available. 1 is in the area of exosome and cancer immunotherapy and the other in chemical synthesis. Priority is given to applicants with experiences in writing papers and grant proposals and capability to work independently.

About PI, Dr. Xin Zhao Dr. Xin Zhao is an assistant professor at the Department of Biomedical Engineering, the Hong Kong Polytechnic University, Hong Kong SAR, China. She obtained her PhD at University College London, UK and postdoc training at Harvard University, USA before joining PolyU. She is dedicated to Translational Regenerative Medicine, integrating multi-disciplinary approaches including material science, cell biology and medicine to modulate cell microenvironments, control cell behaviors and generate tissue-engineered organs, for addressing clinical issues. So far she has published >80 articles in leading journals including Chemical Reviews, Materials Today, PNAS, Advanced Functional Materials, Angewandte Chemie International Edition, Biomaterials. She has successfully attracted grants as principal investigator from Hong Kong Research Grants Council (RGC), Health and Medical Research Fund (HMRF), Innovation and Technology Fund (ITF), National Science Foundation of China (NSFC), private company, etc. Moreover, she has edited two books, authored in 6 book chapters, and holds 5 national patents. She has also chaired sessions or delivered keynote speeches at >30 international conferences, worked as a founding editor for Engineered Regeneration, associate editor for Biointerface Research in Applied Chemistry, guest editor for Drug Discovery Today, Molecules, Polymers, etc. Dr. Zhao strives to provide a stimulating environment with exciting and frontier research topics and excellent colleagues where the candidates can be trained to become outstanding and independent researchers, with sufficient freedom to explore their own ideas while working on well-designed projects. Group website: http://www.zhaobiomaterialsgroup.com/

Remuneration Up to 32000 HKD per month according to applicant’s professional qualifications

Contact

Applicants shall send your CV, publications and three reference letters via email to xin.zhao@polyu.edu.hk.

Click here for the PDF version of this job post at Ankasa Regenerative Therapeutics.

Company Description

Ankasa Regenerative Therapeutics is a venture-backed biotech company based in the San Francisco Bay area that is developing novel protein-based stem cell activation therapies to improve tissue repair and regeneration. Stem cell renewal, maintenance and tissue regeneration are critical for normal health and well-being. Wnt pathway interactions are crucial to maintenance of these processes. Ankasa is the first to produce human Wnt proteins in a GMP manufacturing setting suitable for use in humans.  Our first clinical approach, under FDA regulation, is the demonstration of improved outcomes after spinal fusion surgeries. Our product has expansion opportunities to other bone reconstructive procedures including osseointegration of dental and orthopedic implants (knee and hip replacements), fracture repair, total joint arthroplasty revisions, and others.

Summary / Overall Purpose

We seek a highly motivated PhD level scientist with deep expertise in bone regeneration for a post- doctoral position at Ankasa Regenerative Therapeutics. The primary focus of the role will be the characterization of bone cells / grafts in vitro and in vivo following treatment with our lead regenerative agent. Successful candidates will implement robust, reproducible and cost effective protocols to monitor the viability and regenerative capacity of bone cells / grafts from human and animal bone following treatment, utilizing both in vitro and in vivo models of bone repair, while developing a broad based awareness of the requirements and complexities of the regulatory and commercialization processes for novel biologic and “device-like” therapeutics.

Essential/Primary Duties, Functions and Responsibilities

▪ Independently design and implement robust, reproducible and cost-effective protocols for the isolation, culture, treatment and analysis of cells / grafts from human and animal bone with meticulous aseptic technique.  ▪ Design and implement in vivo studies investigating the regenerative capacity of implanted bone grafts in mice and/or rats (e.g., subrenal capsule implantation, fracture healing, spinal fusion, etc.).  ▪ Design and implement in vivo studies looking at the levels of bone regenerative agents detectable following in vivo delivery.  ▪ Utilize a battery of assay technologies to characterize bone cells / grafts and therapeutic product disposition, including ELISA, qPCR, flow cytometry, immunofluorescence microscopy and histology.  ▪ Independently identify and implement new assays and assay technologies that have an impact

Requirements

Work Experience:  Minimum 4 years laboratory experience as part of a PhD degree program specializing in bone biology/regeneration.

Management of Staff  Not required; however, ability to work well within a team environment is critical

Functional/Technical Knowledge and Skills  ▪ Isolation and culture of cells from human and animal bone  ▪ Isolation, manipulation and implantation of bone grafts (mice, rats)  ▪ Experience with a battery of analytical techniques including qPCR, ELISA, immunofluorescence microscopy, immunohistochemistry and histology

Education/Training  PhD in biology, biomedical engineering, biochemistry, molecular biology, or closely related field, with specific training in bone biology / regeneration

Licenses/Certifications  None required

Other  Work independently on experimental design, execution, and analysis; however, position is well supported by leadership with strong mentoring track record and medical/scientific as well as technology specific expertise; backed by state-of-the-art JLABS infrastructure  Excellent verbal and written communication skills and track record of ability to effectively present scientific data  Detail oriented; proven track record of detailed, reproducible protocol generation that can be readily transferred to other scientists  Positive attitude  Keeps calm under pressure  Occasional weekend work may be required

The Department of Biomedical Engineering at Southern University of Science and Technology has 2 fully-funded postdoctoral fellow positions, available immediately. The successful candidate will be working in Dr. Chao Liu’s research group. The laboratory is well-equipped to study the mechanobiology of stem cell populations during bone repair, and tissue engineering of bone tissue for regenerative medicine applications.

Qualifications

Recent PhD with training documented by publications in international peer-reviewed journals. Successful applicants should have background in biomedical engineering, mechanical engineering, tissue engineering or a related discipline. Knowledge of programming, finite element analysis, in vitro mechanobiology models, and small animal models preferred.

Please send CV and contact information of three references to: Dr. Chao Liu, Email: liuc33@sustech.edu.cn

About the university

Southern University of Science and Technology (SUSTech) is a public university, founded in the lush hills of Nanshan District, Shenzhen, China. It is working towards becoming a world-class university excelling in interdisciplinary research, nurturing innovative talents and delivering new knowledge to the world.

In the Nature Index 2016 Rising Stars rankings, SUSTech was ranked 62nd among the global top 100 institutions with most significant growth in high quality research publications; it ranked as the third fastest growing institution in the world.

Applications are invited for a post-doctoral fellowship position within the Biomechanics Section of the Bone and Joint Center Research Laboratories at Henry Ford Health System (Detroit, MI). The primary research focus will be assessment of vertebral bone quality using new methods based on digital tomosynthesis imaging in a clinical study sponsored by the Department of Defense. The fellow is expected to engage in other projects ongoing within the section.

The successful candidate will be part of a collaborative group with expertise in and facilities for biomechanics, musculoskeletal modeling, computational mechanics, 3D imaging, motion analysis, animal models, cell biology,histology, biochemistry and molecular biology. Scientists in the Bone & Joint Center have a strong history of collaboration with the Departments of Orthopaedic Surgery, Radiology, Public Health Science, Endocrinology, and Rheumatology at Henry Ford Health System. The Henry Ford Bone & Joint Center occupies approximately 15,000 sq ft in Wayne State University’s state-of-the-art Integrative Biosciences Center, which affords additional opportunity for collaboration with the Wayne State University community. Additional information can be found at https://www.hfhsbjc.org/.

Duties and responsibilities, under minimal supervision, will include, 1) planning, carrying out and troubleshooting various experiments that may involve biological specimens or patient data, 2) analyzing and interpreting the data, 3) preparing manuscripts and abstracts for publication, 4) maintaining accurate and efficient functioning of instrumentation used for experiments, and 5) supervising activities of students or other laboratory personnel and participating in educational activities. It is expected that the individual will make an attempt to develop independent projects compatible with their experience level. Support for career development exists for motivated individuals.

Applicants should have a Ph.D. in Mechanical Engineering, Bioengineering or a related field. A dissertation or other research experience in an area related to bone mechanics and musculoskeletal imaging is desired. Good oral and written communication skills are required. Applicants should submit their CV, contact information for three references, and a statement of research interests and career goals to the e-mail address below. The position is available immediately. Applications will be accepted until the position is filled.

Yener N. Yeni, Ph.D.

Head, Section of Biomechanics

Henry Ford Health System

Department of Orthopaedic Surgery

Bone & Joint Center

Integrative Biosciences (iBio) Center

6135 Woodward Ave

Detroit, MI 48202

yeni@bjc.hfh.edu

Henry Ford Hospital is an AA/EO Employer.

A postdoc position is available immediately in the Center for Musculoskeletal Research at the University of Rochester Medical Center. The successful candidate will participate in research program that involves using multiphoton and in vivo imaging as a platform to investigate cellular and molecular mechanisms that orchestrate osteogenesis and angiogenesis during bone defect repair and regeneration. The project integrates bone tissue engineering, vascular biology, and skeletal biology with emphasis on bone regeneration and neovascularization. Strong candidate should have a PhD or equivalent degree and has less than 5 years of postdoctoral training. Published experience with bone biology or vascular biology is preferred. Prior experience with transgenic mice and small animal surgery is a plus. To apply: please send C.V. and names of three references to:

Xinping Zhang, MD, PhD
Associate Professor
Center for Musculoskeletal Research
Department of Orthopaedics and Rehabilitation
University of Rochester Medical Center
601 Elmwood Ave.,
Box 665
Rochester, NY14642
Tel: 585-275-7928
Fax: 585-275-1121
email: xinping_zhang@urmc.rochester.edu

The Mechanics of Biological Materials/Structures Laboratory at the University of Texas at San Antonio (UTSA) is seeking to fill a Postdoctoral Research Associate position working on a NIH supported research project. In this five-year project, we intend to elucidate the effect of proteoglycans on the age-related deterioration of bone quality and to develop therapeutic strategies for preventing or deterring such adverse effect. This position requires a PhD degree in Mechanical Engineering, Biomedical Engineering, Materials Science/Engineering, or a closely related field and willingness to work in a multidisciplinary (engineering, biology, and physics) environment. The incumbent is expected to take a leading role in implementation of the research project and required to help mentor students, publish high impact journal papers, and write grants. Applicants are required to have hands on experience in characterization of mechanical/physical properties of bone or other biological materials. In addition, experiences in AFM and finite element simulations are also preferred.

Interested candidates should send the application as one PDF file containing a letter (explaining research interests, career goals, and qualifications), a CV, and the contact information of at least three references to Dr. Xiaodu Wang using the following contact information.

Xiaodu Wang, Ph.D.

Professor

Department of Mechanical Engineering

University of Texas at San Antonio

One UTSA Circle

San Antonio, TX 78249

Email: xiaodu.wang@utsa.edu

Tel:  1-210-458-5565