Two postdoctoral positions are available immediately in the Department of Pathology & Laboratory Medicine at the University of Rochester Medical Center to work on the basic and translational research related to musculoskeletal disease and breast cancer, funded by multiple NIH R01 and DoD research projects. The musculoskeletal disease project will focus on the interactions among T lymphocytes, macrophage and osteoblasts during aging to cause osteoporosis and immunosenescence through TGFb1-mediated TRAF3 lysosomal degradation and evaluate the effect of our recently patented bone-targeted lysosomal inhibitor on the prevention and treatment of osteoporosis and immunosenescence. The research will involve in sophisticated genetical mouse models, cell fate mapping using flow cytometry coupled with single-cell transcriptomics, three-dimensional imaging and histomorphometry analysis. The breast cancer project will evaluate the effect of a novel engineered macrophage and microbiota-derived LPS on the treatment of metastatic breast cancer in humanized immunocompromised mice coupled with patient-derived xenograft model.
The applicants must have a PhD, MD or MD/PhD degree, be highly motivated with a strong motivation to work independently with good writing and oral communication skills. Prior experience in small animal handling/surgery, flow cytometry, cell culture, immunostaining /confocal microscopy imaging is preferred. Experience in analysis of single cell and bulk RNA-seq, gene cloning, bone histomorphometry, mouse tail vein injection and bone marrow transplantation would be a plus.
To apply for these positions, please email a cover letter and C.V. to:
Zhenqiang Yao, Ph.D.
Department of Pathology & Laboratory Medicine
University of Rochester Medical Center
601 Elmwood Ave., Room 5-7545B
Rochester, NY 14642