ICMRS Scientific Frontier Webinar Series

Discovering skeletal stem cells and their fates in vivo: the power of single-cell sequencing

Presented by Ling Qin, Ph.D.

Associate Professor of Orthopaedic Surgery and Co-Director of PCMD Histology Core at the University of Pennsylvania

When: July 18, 2020 (Saturday) 9:00 PM Eastern Time (US and Canada)

July 18, 2020 (Saturday) 8:00 PM Central Time (US and Canada)

2020年7月19日（星期日）北京时间上午9:00 （中国）

July 19, 2020 (Sunday) 9:00 AM Perth (Australia - Western Australia)

July 19, 2020 (Sunday) 11:00 AM Sydney (Australia - New South Wales)

Short Biography: Dr. Ling Qin is an Associate Professor of Orthopaedic Surgery and Co-Director of PCMD Histology Core at the University of Pennsylvania. She is also an Associate Editor of Journal of Orthopaedic Translation and a member of Editorial Board of Journal of Bone and Mineral Research. She is the current President of International Chinese Musculoskeletal Research Society (ICMRS). She became Fellow of American Society of Bone and Mineral Research (ASBMR) in 2018 and Fellow of International Orthopaedic Research (FIOR) in 2019. To date, she has published more than 90 peer-reviewed research articles, reviewers, and book chapters. The overall goal of her research is to combine studies on fundamental mechanisms of skeletal cell function with translational medicine approaches to treat skeletal diseases. In the past decade, she has made some groundbreaking discoveries that greatly advance our understanding of molecular regulation of bone and cartilage metabolism, stem cell biology, and skeletal development, and provided promising therapeutic tools for skeletal disorders, such as osteoporosis and osteoarthritis.

Abstract: Skeletal stem cells were first identified in bone marrow by Dr. Alexander Friedenstein and coworkers in 1970s. Since then, similar cell culture and transplantation approaches have been applied at many other skeletal tissues, including periosteum, growth plate, synovium, muscle etc, to identify site-specific stem cells. Several decades of research have indicated that those cells are indeed a broad spectrum of mesenchymal progenitors ranging from self-renewal stem cells to transit-amplifying progenitors. Recently, single-cell RNA sequencing technique emerged as the most powerful approach to solve heterogeneity in complex organs. This webinar will summarize the achievements made in this area in the past two years from our group and others, with a special focus on bone marrow mesenchymal stem cells and their in vivo stepwise evolvement into functional, differentiated cells that not only contribute to bone formation but also become a master regulator of bone marrow environment.

This webinar will be moderated by Dr. Wentian Yang, Associate Professor of Orthopedics and Associate Professor of Medicine, Brown University Alpert Medical School.

If you are not able to attend ICMRS webinars, you are welcome to click here for recorded videos from ICMRS Scientific Frontier Webinar Series.

For more information, please contact:

Jean Jiang, PhD

Chair, Education Committee, ICMRS

Professor and Zachry Distinguished University Chair

Department of Biochemistry and Structural Biology

University of Texas Health Science Center at San Antonio