ICMRS Scientific Frontier Webinar Series
The Role(s) of PTPN11 in Skeletal Development and Diseases
Presented by Wentian Yang, Ph.D.
Associate Professor of Orthopedics and Associate Professor of Medicine, Brown University Alpert Medical School, Rhode Island, U.S.A.
When: September 26, 2020 (Saturday) 9:00 PM Eastern Time (US and Canada)
September 26, 2020 (Saturday) 8:00 PM Central Time (US and Canada)
September 27, 2020 (Sunday) 9:00 AM Perth (Australia - Western Australia)
September 27, 2020 (Sunday) 11:00 AM Sydney (Australia - New South Wales)
Where: an email will be sent to the members of the ICMRS with a link for Zoom Video Conference.
Short Biography: Dr. Yang’s research focuses on elucidating the role of protein tyrosine phosphatases in skeletal health and diseases. Most of the work on protein modification in the skeletal system have been focused on phosphorylation by kinases, while there is minimal investigation on the dephosphorylation by protein phosphatases, which can have equally profound functional consequences. Over the past decade, Dr. Yang’s laboratory has been investigating how bone and cartilage development and homeostasis are regulated by the Src homology 2-domain containing tyrosine phosphatase SHP2, encoded by PTPN11. They discovered a novel population of cathepsin K (Ctsk)-expressing skeletal stem cells (CSC) and found that SHP2 deficiency in CSC causes human cartilage tumor syndrome metachondromatosis (Nature, 2013; PloS Genet 2014, Bone Research 2018). His lab also reported SHP2’s requirement in osteoclastogenesis by promoting the fusion of preosteoclasts (FASEBJ, 2015, 2018). Early in his career, Dr. Yang made contributions to the discoveries of SHP2 as a key regulator of the Src family kinase activation (Molecular Cell, 2004), embryonic and tissue stem cell survival (Developmental Cell, 2006), normal hematopoiesis and hematopoietic malignancy (Blood, 2009 & 2011; Leukemia 2018), and the pathogenesis of Noonan syndrome (Nature Medicine, 2006). In this ICMRS Webinar, Dr. Yang will discuss his team’s recent findings regarding the cellular context-specific role of PTPN11 in the skeletal system and its potential mechanism(s).
This webinar will be moderated by Dr. Mei Wan, Professor, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine.
If you are not able to attend ICMRS webinars, you are welcome to click here for recorded videos from ICMRS Scientific Frontier Webinar Series.
For more information, please contact:
Jean Jiang, PhD
Chair, Education Committee, ICMRS
Professor and Zachry Distinguished University Chair
Department of Biochemistry and Structural Biology
University of Texas Health Science Center at San Antonio