ICMRS Scientific Frontier Webinar Series
Engineering the molecular dynamics of polymeric biomaterials for regulating cellular functions
Presented by Liming Bian, Ph.D.
Associate Professor, Department of Biomedical Engineering, the Chinese University of Hong
Note: unusual time
When: October 9, 2020 (Friday) 9:00 PM Eastern Time (US and Canada)
October 9, 2020 (Friday) 8:00 PM Central Time (US and Canada)
October 10, 2020 (Saturday) 9:00 AM Perth (Australia - Western Australia)
October 10, 2020 (Saturday) 11:00 AM Sydney (Australia - New South Wales)
Where: Click here to view the recorded webinar.
Short Biography: Dr. Liming Bian is currently an associate professor in the Department of Biomedical Engineering at the Chinese University of Hong Kong. Dr. Bian completed his Ph.D. study in Biomedical Engineering at Columbia University in 2009. Dr. Liming Bian then conducted his postdoctoral research in the Department of Bioengineering, the University of Pennsylvania from 2009 to 2012. In 2012, Dr. Bian joined the Chinese University of Hong Kong as an assistant professor. Dr. Bian’s research focuses on the development of novel multiscale biomaterials not only for investigating the role of cell microenvironment factors on stem cell behaviors but also for facilitating the regeneration of diseased or injured tissues and organs.
Abstract: The dynamic properties of polymeric biomaterials at molecular level impart significant impact on the cellular behaviors. Developing tunable molecularly-dynamic polymeric biomaterials is highly instrumental to the fundamental investigation on cellular responses to the dynamic cues in extracellular environment. For example, cellular adhesion is controlled by the dynamic ligation process of surface receptors, such as integrin, to adhesive motifs, such as Arg-Gly-Asp (RGD). Remote control of adhesive ligand presentation on biomaterial surfaces can offer benefits in regulating cell–implant interactions thereby immune responses or tissue regeneration in vivo. Herein we present strategies for modulating nanoscale ligand oscillations on 2D biomaterial substrates to modulate the adhesion and specialization of stem cells and macrophages. To investigate 3D culture of cells in hydrogels with dynamic network structures, we have developed a series of dynamic hydrogels based on reversible crosslinks with unique properties such as resilient mechanical property, fast relaxation, self-healing, bioadhesiveness, injectability, and promoting recruitment of endogenous cells. These hydrogel properties are not only desirable for potential clinical applications of these hydrogels but also useful for studying the effect of microenvironmental mechanical cues on stem cell behaviors.
This webinar will be moderated by Dr. Bin Li, Professor, Department of Orthopaedic Surgery, Soochow University.
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For more information, please contact:
Jean Jiang, PhD
Chair, Education Committee, ICMRS
Professor and Zachry Distinguished University Chair
Department of Biochemistry and Structural Biology
University of Texas Health Science Center at San AntonioEmail: email@example.com